Fixed dose prothrombin complex concentrate for the reversal of oral anticoagulation therapy

被引：15

作者：

Junagade, P. ^{[1
]}

Grace, R. ^{[1
]}

Gover, P. ^{[1
]}

机构：

[1] Eastbourne Dist Gen Hosp, Dept Haematol, Eastbourne BN21 2UD, E Sussex, England

来源：

HEMATOLOGY | 2007年 / 12卷 / 05期

关键词：

D O I：

10.1080/10245330701448529

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Warfarin reversal is frequently required in day to day haematology practice. Prothrombin complex concentrates (PCC) have replaced fresh frozen plasma as the agent of choice in warfarin reversal due to its safety profile. Ideal dose of PCC is still not known and many centres have local guidelines on using the product. We have successfully used PCC (Beriplex) at a fixed dose in our hospital, but we still need randomised control trials to identify the ideal dose of PCC which can result in rapid reversal of warfarin with minimum risk of thrombosis.

引用

页码：439 / 440

页数：2

共 4 条

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Eijkhout, Heleen W.
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Ploeger, Ben
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[3] Optimal dose of prothrombin complex concentrate for acute reversal of oral anticoagulation
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Sakata, T
Naritomi, H
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[J]. THROMBOSIS RESEARCH, 2005, 115 (06) : 455 - 459
[4] BR J HAEMATOL, V101, P374

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