Evidence for a histaminergic system in the human testis

被引：32

作者：

Albrecht, M

Frungieri, MB

Gonzalez-Calvar, S

Meineke, V

Köhn, FM

Mayerhofer, A

机构：

[1] Univ Munich, Anat Inst Biederstein, D-80802 Munich, Germany

[2] Inst Biol & Med Expt, RA-1428 Buenos Aires, DF, Argentina

[3] Sanitatsakad Bundeswehr, Inst Strahlenbiol, Munich, Germany

[4] Tech Univ Munich, Dept Dermatol & Allergy, Munich, Germany

来源：

FERTILITY AND STERILITY | 2005年 / 83卷 / 04期

关键词：

D O I：

10.1016/j.fertnstert.2004.12.002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The complete lack of information about mast cells as a source of histamine and potential target cells for histamine in human testes prompted us to investigate these issues in testes of fertile and infertile patients using a combination of laser microdissection, reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemistry. We show for the first time the expression of the rate-limiting enzyme in histamine synthesis-histidine decarboxylase-by human testicular mast cells and the expression of the histamine (H) receptors 1 (H1) and 2 (H2) by germinal, interstitial, and peritubular cells in the testes of fertile and infertile patients. (c) 2005 by American Society for Reproductive Medicine.

引用

页码：1060 / 1063

页数：4

共 13 条

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