Desensitization of postsynaptic glutamate receptors contributes to high-frequency homosynaptic depression of Aplysia sensorimotor connections

被引:15
作者
Antzoulatos, EG
Cleary, LJ
Eskin, A
Baxter, DA
Byrne, JH [1 ]
机构
[1] Univ Texas, Houston Med Sch, WM Keck Ctr Neurobiol Learning & Memory, Dept Neurobiol & Anat, Houston, TX 77030 USA
[2] Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA
关键词
D O I
10.1101/lm.61403
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Withdrawal reflexes of Aplysia are mediated in part by a monosynaptic circuit of sensory (SN) and motor (MN) neurons. A brief high-frequency burst of spikes in the SN produces excitatory postsynaptic potentials (EPSPs) that rapidly decrease in amplitude during the burst of activity. It is generally believed that this and other (i.e., low-frequency) forms of homosynaptic depression are entirely caused by presynaptic mechanisms (e.g., depletion of releasable transmitter). The present study examines the contribution that desensitization of postsynaptic glutamate receptors makes to homosynaptic depression. Bath application of cyclothiazide, an agent that reduces desensitization of non-NMDA glutamate receptors, reduced high-, but not low-frequency synaptic depression. Thus, a postsynaptic mechanism, desensitization of glutamate receptors, call also contribute to homosynaptic depression of sensorimotor synapses.
引用
收藏
页码:309 / 313
页数:5
相关论文
共 53 条
[1]   Activity-dependent presynaptic facilitation and Hebbian LTP are both required and interact during classical conditioning in Aplysia [J].
Antonov, I ;
Antonova, I ;
Kandel, ER ;
Hawkins, RD .
NEURON, 2003, 37 (01) :135-147
[2]  
Antonov I, 1999, J NEUROSCI, V19, P10438
[3]   The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization [J].
Arai, A ;
Lynch, G .
BRAIN RESEARCH, 1998, 799 (02) :230-234
[4]  
Armitage BA, 1998, J NEUROSCI, V18, P8770
[5]   MORPHOLOGICAL BASIS OF LONG-TERM HABITUATION AND SENSITIZATION IN APLYSIA [J].
BAILEY, CH ;
CHEN, M .
SCIENCE, 1983, 220 (4592) :91-93
[6]  
BAILEY CH, 1988, J NEUROSCI, V8, P2452
[7]   A novel presynaptic inhibitory mechanism underlies paired pulse depression at a fast central synapse [J].
Bellingham, MC ;
Walmsley, B .
NEURON, 1999, 23 (01) :159-170
[8]   RECEPTIVE-FIELDS AND RESPONSE PROPERTIES OF MECHANORECEPTOR NEURONS INNERVATING SIPHON SKIN AND MANTLE SHELF IN APLYSIA [J].
BYRNE, J ;
CASTELLU.V ;
KANDEL, ER .
JOURNAL OF NEUROPHYSIOLOGY, 1974, 37 (05) :1041-1064
[9]   ANALYSIS OF SYNAPTIC DEPRESSION CONTRIBUTING TO HABITUATION OF GILL-WITHDRAWAL REFLEX IN APLYSIA-CALIFORNICA [J].
BYRNE, JH .
JOURNAL OF NEUROPHYSIOLOGY, 1982, 48 (02) :431-438
[10]   STIMULUS-RESPONSE RELATIONS AND STABILITY OF MECHANORECEPTOR AND MOTOR NEURONS MEDIATING DEFENSIVE GILL-WITHDRAWAL REFLEX IN APLYSIA [J].
BYRNE, JH ;
CASTELLUCCI, VF ;
CAREW, TJ ;
KANDEL, ER .
JOURNAL OF NEUROPHYSIOLOGY, 1978, 41 (02) :402-417