Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors

被引：31

作者：

Koh, Yasuhiro

Matreyek, Kenneth A.

Engelman, Alan ^{[1
]}

机构：

[1] Harvard Univ, Dept Canc Immunol & AIDS, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 07期

关键词：

IMMUNODEFICIENCY-VIRUS INTEGRASE; HIV-1; INTEGRASE; CRYSTAL-STRUCTURE; FOAMY VIRUS; IN-VITRO; RALTEGRAVIR; RESISTANCE; REPLICATION; INFECTION; EVOLUTION;

D O I：

10.1128/JVI.02541-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Integrase inhibitors are emerging anti-human immunodeficiency virus (HIV) drugs, and multiple retroviruses and transposable elements were evaluated here for susceptibilities to raltegravir (RAL) and elvitegravir (EVG). All viruses, including primate and nonprimate lentiviruses, a Betaretrovirus, a Gammaretrovirus, and the Alpharetrovirus Rous sarcoma virus (RSV), were susceptible to inhibition by RAL. EVG potently inhibited all lentiviruses and intermediately inhibited Betaretrovirus and Gammaretrovirus infections yet was basically ineffective against RSV. Substitutions based on HIV type 1 (HIV-1) resistance changes revealed that integrase residue Ser150 contributed significantly to the resistance of RSV. The drugs intermediately inhibited intracisternal A-particle retrotransposition but were inactive against Sleeping Beauty transposition and long interspersed nucleotide element 1 (LINE-1) retrotransposition.

引用

页码：3677 / 3682

页数：6

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