Research in hand osteoarthritis: Time for reappraisal and demand for new strategies. An opinion paper

被引：54

作者：

Kloppenburg, Margreet ^{[1
]}

Stamm, Tanja ^{[1
]}

Watt, Iain ^{[1
]}

Kainberger, Franz ^{[1
]}

Cawston, Tim E. ^{[1
]}

Birrell, Fraser N. ^{[1
]}

Petersson, Ingemar F. ^{[1
]}

Saxne, Tore ^{[1
]}

Kvien, Tore K. ^{[1
]}

Slatkowsky-Christensen, Barbara ^{[1
]}

Dougados, Maxime ^{[1
]}

Gossec, Laure ^{[1
]}

Breedveld, Ferdinand C. ^{[1
]}

Smolen, Josef S. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2007年 / 66卷 / 09期

关键词：

D O I：

10.1136/ard.2007.070813

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA ( DICHOA) initiative was founded in early 2005 with the aim of addressing key issues and facilitating research into hand osteoarthritis. Objective: To review and discuss current knowledge on hand osteoarthritis with regard to aetiopathogenesis, diagnostic criteria, biomarkers and clinical outcome measures. Methods: Recommendations were made based on a literature review. Results: Outcomes of hand osteoarthritis should be explored, including patient perspective on the separate components of disease activity, damage and functioning. All imaging techniques should be cross-validated for hand osteoarthritis with clinical status, including disease activity, function and performance, biomarkers and long-term outcome. New imaging modalities are available and need scoring systems and validation. The role of biomarkers in hand osteoarthritis has to be defined. Conclusion: Future research in hand osteoarthritis is warranted.

引用

页码：1157 / 1161

页数：5

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