Longitudinal mechanics of the periinfarct zone and ventricular tachycardia inducibility in patients with chronic ischemic cardiomyopathy

被引：19

作者：

Bertini, Matteo ^{[1
,2
]}

Ng, Arnold C. T. ^{[1
]}

Borleffs, C. Jan Willem ^{[1
]}

Delgado, Victoria ^{[1
]}

Wijnmaalen, Adrianus P. ^{[1
]}

Nucifora, Gaetano ^{[1
]}

Ewe, See H. ^{[1
]}

Shanks, Miriam ^{[1
]}

Thijssen, Joep ^{[1
]}

Zeppenfeld, Katja ^{[1
]}

Biffi, Mauro ^{[2
]}

Leung, Dominic Y. ^{[3
]}

Schalij, Martin J. ^{[1
]}

Bax, Jeroen J. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Cardiol, NL-2333 ZA Leiden, Netherlands

[2] Univ Bologna, Dept Cardiol, Bologna, Italy

[3] Univ New S Wales, Dept Cardiol, Sydney, NSW, Australia

来源：

AMERICAN HEART JOURNAL | 2010年 / 160卷 / 04期

关键词：

INFARCT TISSUE HETEROGENEITY; CORONARY-ARTERY-DISEASE; SUDDEN CARDIAC DEATH; BORDER ZONE; POSTMYOCARDIAL INFARCTION; MYOCARDIAL-INFARCTION; STRAIN; ABLATION; ECHOCARDIOGRAPHY; ARRHYTHMIA;

D O I：

10.1016/j.ahj.2010.06.041

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background Quantification of segmental left ventricular (LV) strain by speckle-tracking echocardiography can identify transmural infarcts in patients with chronic ischemic cardiomyopathy. The aim of the study was to explore the relationship between the LV longitudinal peak systolic strain (LPSS) of the infarct, periinfarct, and remote zones and monomorphic ventricular tachycardia (VT) inducibility on electrophysiologic (EP) study. Methods A total of 134 patients with chronic ischemic cardiomyopathy scheduled for EP study were included. The protocol consisted of clinical, electrocardiographic, and echocardiographic evaluation, including LV longitudinal strain analysis using speckle-tracking echocardiography, immediately before EP study. An infarct segment was defined as a longitudinal strain value of greater than -5%, and a periinfarct segment was defined as immediately adjacent to an infarct segment. Results The infarct zone had the most impaired longitudinal strain (-0.5% +/- 3.0%), whereas the periinfarct and remote zones had more preserved longitudinal strain (-10.8% +/- 1.9% and -14.5% +/- 3.0%, respectively; analysis of variance, P < .001). Seventy-two (54%) patients had inducible monomorphic VT on EP study. There was no significant difference in LV ejection fraction (31% +/- 9% vs 32% +/- 11%, P = .29) between inducible and noninducible patients. Longitudinal peak systolic strain of the periinfarct zone was more impaired in inducible patients (-9.8% +/- 1.5% vs -11.0% +/- 2.1%, P = .001), but no differences in LPSS of the infarct (-0.5% +/- 3.2% vs -0.4% +/- 2.7%, P = .75) and remote (-14.6% +/- 2.8% vs -14.5% +/- 3.4%, P = .92) zones were observed. Only LPSS of the periinfarct zone (OR 1.43, 95% CI 1.15-1.78, P = .001) was independently related to monomorphic VT inducibility on multiple logistic regression. Conclusions Longitudinal strain analysis may be a useful imaging tool to risk stratify ischemic patients for malignant ventricular arrhythmia. (Am Heart J 2010; 160: 729-36.)

引用

页码：729 / 736

页数：8

共 19 条

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