Cardiovascular characteristics in American youth with prehypertension

被引:55
作者
Zhu, Haidong [1 ]
Yan, Weili [1 ]
Ge, Dongliang [1 ]
Treiber, Frank A. [1 ]
Harshfield, Gregory A. [1 ]
Kapuku, Gaston [1 ]
Snieder, Harold [1 ]
Dong, Yanbin [1 ]
机构
[1] Med Coll Georgia, Dept Pediat, Georgia Prevent Inst, Augusta, GA 30912 USA
关键词
prehypertension; youth; arterial stiffness; hemodynamics; left-ventricular structure and function; ambulatory blood pressure;
D O I
10.1016/j.amjhyper.2007.05.009
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: Cardiovascular structure and function in youth with prehypertension have been incompletely investigated. Methods: Casual and ambulatory blood pressure (BP) measurement, arterial stiffness, noninvasive hemodynamic profiles, and cardiac structure were studied in a twin cohort of American black and white youth (n = 942; mean age, 17.6 +/- 3.3 years SD). A family history of essential hypertension was used as a proxy to study genetic susceptibility to prehypertension. Results: The occurrence of prehypertension was approximately 12% in the entire sample. Body mass index and waist circumference were significantly greater in prehypertensive subjects than in normotensive subjects. The 24-h ambulatory systolic BP (SBP), 24-h ambulatory diastolic BP (DBP), nighttime ambulatory SBP, and nighttime ambulatory DBP were significantly elevated in prehypertensive subjects compared with normotensive subjects. In whites, prehypertensive subjects compared with normotensive subjects showed increased radial (6.8 +/- 0.1 v 6.2 +/- 0.1 m/sec, P < .001) and foot pulse-wave velocity (PWV) (7.4 +/- 0.1 v 7.0 +/- 0.1 m/sec, P = .001). In whites, the total peripheral resistance index was greater in prehypertensive subjects than in normotensive subjects (P = .005). White prehypertensive subjects had a significantly greater heart rate than white normotensive subjects (69.0 +/- 1.4 v 64.0 +/- 0.6 bpm). In contrast, in blacks, the cardiac index was higher in prehypertensive subjects than 2 in normotensive subjects (3.3 +/- 0.1 v 3.0 +/- 0.1 L/min/m(2), P = .004). In blacks and whites, there were no statistical differences in the parameters of left-ventricular structure between normotensive subjects and prehypertensive subjects. Finally, prehypertensive subjects were more likely to have a positive family history of essential hypertension, especially in blacks. Conclusions: Prehypertension compared with normotension exhibited unfavorable cardiovascular phenotypes. Cardiovascular characteristics of prehypertension appear to be race-dependent.
引用
收藏
页码:1051 / 1057
页数:7
相关论文
共 30 条
[1]   Noninvasive hemodynamic profiles in hypertensive subjects [J].
Abdelhammed, AI ;
Smith, RD ;
Levy, P ;
Smits, GJ ;
Ferrario, CM .
AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (02) :51S-59S
[2]  
Andrew T, 2001, Twin Res, V4, P464, DOI 10.1375/twin.4.6.464
[3]   A cell cycle controller rewrites its CV [J].
Brooksbank, C .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :3-4
[4]   Prehypertension revisited [J].
Chobanian, Aram V. .
HYPERTENSION, 2006, 48 (05) :812-814
[5]   Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [J].
Chobanian, AV ;
Bakris, GL ;
Black, HR ;
Cushman, WC ;
Green, LA ;
Izzo, JL ;
Jones, DW ;
Materson, BJ ;
Oparil, S ;
Wright, JT ;
Roccella, EJ .
HYPERTENSION, 2003, 42 (06) :1206-1252
[6]   LEFT-VENTRICULAR MASS AND BODY SIZE IN NORMOTENSIVE CHILDREN AND ADULTS - ASSESSMENT OF ALLOMETRIC RELATIONS AND IMPACT OF OVERWEIGHT [J].
DESIMONE, G ;
DANIELS, SR ;
DEVEREUX, RB ;
MEYER, RA ;
ROMAN, MJ ;
DEDIVITIIS, O ;
ALDERMAN, MH .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 20 (05) :1251-1260
[7]   ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT-VENTRICULAR HYPERTROPHY - COMPARISON TO NECROPSY FINDINGS [J].
DEVEREUX, RB ;
ALONSO, DR ;
LUTAS, EM ;
GOTTLIEB, GJ ;
CAMPO, E ;
SACHS, I ;
REICHEK, N .
AMERICAN JOURNAL OF CARDIOLOGY, 1986, 57 (06) :450-458
[8]   Hypertension-related morbidity and mortality in the southeastern United States [J].
Hall, WD ;
Ferrario, CM ;
Moore, MA ;
Hall, JE ;
Flack, JM ;
Cooper, W ;
Simmons, JD ;
Egan, BM ;
Lackland, DT ;
Perry, M ;
Roccella, EJ .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1997, 313 (04) :195-209
[9]  
Harshfield GA, 2000, BLOOD PRESS MONIT, V5, P59
[10]   Prehypertension and obesity in adolescents - A population study [J].
Israeli, Eran ;
Schochat, Tzippy ;
Korzets, Ze'ev ;
Tekes-Manova, Dorit ;
Bernheim, Jacques ;
Golan, Eliezer .
AMERICAN JOURNAL OF HYPERTENSION, 2006, 19 (07) :708-712