Integron-mediated antibiotic multiresistance in Acinetobacter baumannii clinical isolates from Spain

被引：35

作者：

Ruiz, J ^{[1
]}

Navia, MM ^{[1
]}

Casals, C ^{[1
]}

Sierra, JM ^{[1
]}

De Anta, MTJ ^{[1
]}

Vila, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Med, Hosp Clin, IDIBAPS,Inst Clin Infecc & Immunol Clin, Barcelona 08036, Spain

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2003年 / 9卷 / 09期

关键词：

integron; Acinetobacter baumannii; resistance;

D O I：

10.1046/j.1469-0691.2003.00561.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective To determine whether non-epidemiologically related, antibiotic-resistant isolates of Acinetobacter baumannii from different geographical origins posses common type 1 integrons. Methods The epidemiologic relationships between seven A. baumannii strains recovered from different Spanish hospitals were established by pulsed-field gel electrophoresis, the presence of integrons being determined by PCR and DNA sequencing. Results Integron analysis showed the presence of four different integrons, containing six different known genes (aacC1, aacA4, aadA1, aadB, oxa21 and oxa37) plus an ORF. It was found that the same integron was present in different unrelated strains and that related strains could have different integrons. Conclusion These results show the potential risk of integron dissemination among different strains of A. baumannii.

引用

页码：907 / 911

页数：5

共 29 条

[1] Acinetobacter spp, as nosocomial pathogens: Microbiological, clinical, and epidemiological features [J].

BergogneBerezin, E ;

Towner, KJ .

CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (02) :148-+

[2] CHARACTERIZATION OF IN0 OF PSEUDOMONAS-AERUGINOSA PLASMID PVS1, AN ANCESTOR OF INTEGRONS OF MULTIRESISTANCE PLASMIDS AND TRANSPOSONS OF GRAM-NEGATIVE BACTERIA [J].

BISSONNETTE, L ;

ROY, PH .

JOURNAL OF BACTERIOLOGY, 1992, 174 (04) :1248-1257

[3] TAXONOMY OF THE GENUS ACINETOBACTER WITH THE RECOGNITION OF ACINETOBACTER-BAUMANNII SP-NOV, ACINETOBACTER-HAEMOLYTICUS SP-NOV, ACINETOBACTER-JOHNSONII SP-NOV, AND ACINETOBACTER-JUNII SP-NOV AND EMENDED DESCRIPTIONS OF ACINETOBACTER-CALCOACETICUS AND ACINETOBACTER-LWOFFII [J].

BOUVET, PJM ;

GRIMONT, PAD .

INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1986, 36 (02) :228-240

[4] Plasmid pDGO100 contains a second integron with the trimethoprim resistance gene dfrA7 as the inserted cassette [J].

Burnside, JM ;

Obbink, DJG .

PLASMID, 1996, 35 (01) :67-70

[5] SITE-SPECIFIC DELETION AND REARRANGEMENT OF INTEGRON INSERT GENES CATALYZED BY THE INTEGRON DNA INTEGRASE [J].

COLLIS, CM ;

HALL, RM .

JOURNAL OF BACTERIOLOGY, 1992, 174 (05) :1574-1585

[6] TRANSPOSON-MEDIATED MULTIPLE ANTIBIOTIC-RESISTANCE IN ACINETOBACTER STRAINS [J].

DEVAUD, M ;

KAYSER, FH ;

BACHI, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 22 (02) :323-329

[7] Carriage of class 1 integrons and antibiotic resistance in clinical isolates of Acinetobacter baumannii from Northern Spain [J].

Gallego, L ;

Towner, KJ .

JOURNAL OF MEDICAL MICROBIOLOGY, 2001, 50 (01) :71-77

[8] Rapid pulsed-field gel electrophoresis protocol for typing of Escherichia coli O157:H7 and other gram-negative organisms in 1 day [J].

Gautom, RK .

JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (11) :2977-2980

[9] CLINICAL AND MOLECULAR EPIDEMIOLOGY OF ACINETOBACTER INFECTIONS SENSITIVE ONLY TO POLYMYXIN-B AND SULBACTAM [J].

GO, ES ;

URBAN, C ;

BURNS, J ;

KREISWIRTH, B ;

EISNER, W ;

MARIANO, N ;

MOSINKASNIPAS, K ;

RAHAL, JJ .

LANCET, 1994, 344 (8933) :1329-1332

[10] TRANSFERABLE PLASMID-MEDIATED ANTIBIOTIC-RESISTANCE IN ACINETOBACTER [J].

GOLDSTEIN, FW ;

LABIGNEROUSSEL, A ;

GERBAUD, G ;

CARLIER, C ;

COLLATZ, E ;

COURVALIN, P .

PLASMID, 1983, 10 (02) :138-147

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