Resolution of enantiomers of ketoprofen by HPLC: a review

被引：27

作者：

Mullangi, R

Yao, M

Srinivas, NR ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Drug Dev Discovery Res, Bioanalysis Metab & Pharmacokinet Labs, Hyderabad, Andhra Pradesh, India

[2] Henan Univ, Lab Lubricat & Funct Mat, Kaifeng 475001, Peoples R China

来源：

BIOMEDICAL CHROMATOGRAPHY | 2003年 / 17卷 / 07期

关键词：

ketoprofen enantiomers; HPLC; resolution; review;

D O I：

10.1002/bmc.277

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Today, a heightened awareness of the applicability of enantiomers in medicine and clinical practice has been generated due to the continuous evolvement of the field of chirality. In this context, this article provides a review of separation of ketoprofen. an important drug,, in a popular class of non-steroidal anti-inflammatory drugs (i.e. profens). This review highlights various methodologies. logistical considerations for separation and provides an exhaustive list of applications mainly focusing on the pharmacokinetic aspects. Clearly, the application of enantioselective methods for drug racemates paves the way to understand the in vivo behavior of individual enantionter and hence an opportunity for an alternate and/or better option for treating the disease. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：423 / 434

页数：12

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