Harmonization of magnetic resonance-based manual hippocampal segmentation: A mandatory step for wide clinical use

被引：67

作者：

Frisoni, Giovanni B. ^{[1
]}

Jack, Clifford R. ^{[2
]}

机构：

[1] IRCCS San Giovanni Dio Fatebenefratelli, LENITEM Lab Epidemiol Neuroimaging & Telemed, Brescia, Italy

[2] Mayo Clin, Dept Diagnost Radiol, Rochester, MN USA

来源：

ALZHEIMERS & DEMENTIA | 2011年 / 7卷 / 02期

关键词：

Alzheimer's disease; Hippocampal volumetry; MR imaging; Early diagnosis; Clinical trials; Outcome measures; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; AUTOMATED SEGMENTATION; CEREBRAL VOLUME; VALIDATION; ATROPHY;

D O I：

10.1016/j.jalz.2010.06.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hippocampal atrophy is a marker of disease state and progression in Alzheimer's disease. The gold standard to measure hippocampal volume is through manual segmentation. A number of protocols to measure hippocampal volume through manual segmentation have been developed, but the marked heterogeneity of anatomical landmarks has given rise to wide variability of volume estimates. With the aim of fostering the use of hippocampal volume in routine clinical settings, an international task force is currently working on developing a harmonized protocol that will resolve and reduce the present heterogeneity. The task force will then validate the harmonized protocol, develop harmonized probabilistic hippocampal maps, and develop illustrative and educational material on the use of the harmonized protocol and maps. (C) 2011 The Alzheimer's Association. All rights reserved.

引用

页码：171 / 174

页数：4

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