Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat

被引：113

作者：

Sahu, A ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Physiol & Cell Biol, Pittsburgh, PA 15261 USA

来源：

ENDOCRINOLOGY | 1998年 / 139卷 / 11期

关键词：

D O I：

10.1210/en.139.11.4739

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence suggests that leptin reduces food intake (FI) by acting at the hypothalamic level. Leptin decreases hypothalamic neuropeptide Y (NPY), melanin-concentrating hormone (MCH) and galanin (GAL) gene expression in rats. The purpose of the present study was to test the hypothesis that leptin decreases FI by additionally modulating the action of NPY, MCH or GAL in the hypothalamus. Intracerebroventricular (icv) administration of NPY, MCH or GAL induced FI in satiated rats. A prior icy injection of leptin (4 mu g) completely prevented the increase of FI either by MCH, GAL or NPY. These results suggest that modulation of post-synaptic actions of MCH, GAL and NPY is one of the mechanisms of leptin signaling in the hypothalamus.

引用

页码：4739 / 4742

页数：4

共 28 条

[1] GALANIN-CONTAINING NEURONS IN THE PARAVENTRICULAR NUCLEUS - A NEUROCHEMICAL MARKER FOR FAT INGESTION AND BODY-WEIGHT GAIN
AKABAYASHI, A
KOENIG, JI
WATANABE, Y
ALEXANDER, JT
LEIBOWITZ, SF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (22) : 10375 - 10379
[2] ALBARAZANJI KA, 1998, ENDOCRINOLOGY, V139, P795
[3] Leptin is a metabolic signal to the reproductive system
Barash, IA
Cheung, CC
Weigle, DS
Ren, HP
Kabigting, EB
Kuijper, JL
Clifton, DK
Steiner, RA
[J]. ENDOCRINOLOGY, 1996, 137 (07) : 3144 - 3147
[4] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS
CAMPFIELD, LA
SMITH, FJ
GUISEZ, Y
DEVOS, R
BURN, P
[J]. SCIENCE, 1995, 269 (5223) : 546 - 549
[5] Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
Chehab, FE
Lim, ME
Lu, RH
[J]. NATURE GENETICS, 1996, 12 (03) : 318 - 320
[6] The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically Obese falfa rats - Reduced sensitivity compared with lean animals
Cusin, I
RohnerJeanrenaud, F
StrickerKrongrad, A
Jeanrenaud, B
[J]. DIABETES, 1996, 45 (10) : 1446 - 1451
[7] Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
Erickson, JC
Clegg, KE
Palmiter, RD
[J]. NATURE, 1996, 381 (6581) : 415 - 418
[8] WEIGHT-REDUCING EFFECTS OF THE PLASMA-PROTEIN ENCODED BY THE OBESE GENE
HALAAS, JL
GAJIWALA, KS
MAFFEI, M
COHEN, SL
CHAIT, BT
RABINOWITZ, D
LALLONE, RL
BURLEY, SK
FRIEDMAN, JM
[J]. SCIENCE, 1995, 269 (5223) : 543 - 546
[9] Nutritional infertility: The role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network
Kalra, SP
Kalra, PS
[J]. FRONTIERS IN NEUROENDOCRINOLOGY, 1996, 17 (04) : 371 - 401
[10] Abnormal splicing of the leptin receptor in diabetic mice
Lee, GH
Proenca, R
Montez, JM
Carroll, KM
Darvishzadeh, JG
Lee, JI
Friedman, JM
[J]. NATURE, 1996, 379 (6566) : 632 - 635

← 1 2 3 →