The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis

被引：48

作者：

Rubinstein, Tamar ^{[1
]}

Pitashny, Milena ^{[1
,2
]}

Putterman, Chaim ^{[1
,3
]}

机构：

[1] Albert Einstein Coll Med, Div Rheumatol, Dept Med, Bronx, NY 10461 USA

[2] Hadassah Univ Hosp, Dept Microbiol & Infect Dis, IL-91120 Jerusalem, Israel

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

AUTOIMMUNITY REVIEWS | 2008年 / 7卷 / 03期

关键词：

neutrophil gelatinase-B associated lipocalin; NGAL; Lipocalin-2; systemic lupus erythematosus; lupus nephritis; biomarkers;

D O I：

10.1016/j.autrev.2007.11.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lupus nephritis, a potentially devastating outcome of systemic lupus erythematosus (SLE), poses a real challenge in the management of SLE patients because of the difficulty in diagnosing its onset and identifying relapses before serious renal damage has ensued. Neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 has been implicated in the pathogenesis of several disease states in different organ systems, and especially in kidney diseases. Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism. Clinically, urinary Lipocalin-2 significantly correlates with measures of lupus nephritis disease activity, and may be an important and convenient marker for relapses. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：229 / 234

页数：6

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