In vitro gene delivery by a novel human calcitonin (hCT)-derived carrier peptide

被引：37

作者：

Krauss, U ^{[1
]}

Müller, M ^{[1
]}

Stahl, M ^{[1
]}

Beck-Sickinger, AG ^{[1
]}

机构：

[1] Univ Leipzig, Inst Biochem, D-04103 Leipzig, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 01期

关键词：

carrier peptide; genetherapy; translocation;

D O I：

10.1016/j.bmcl.2003.10.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gene therapy still awaits a broader application, since safe and efficient gene delivery is a major problem. Also for the investigation of signal transduction and intracellular trafficking, delivery systems for hydrophilic macromolecules that are easy to use are needed. Several peptide-based delivery systems have been developed during the last years. We present here a novel carrier peptide derived from human calcitonin that is capable of transfecting human neuroblastoma cells by complex formation with a plasmid. Because of the peptide's physiological origin, cytotoxic effects are not expected. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：51 / 54

页数：4

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