Titanium-promoted enantioselective diethylzinc addition to benzaldehyde in the presence of C2-symmetrical bis(camphorsulfonamide) ligands

被引：10

作者：

Bauer, T ^{[1
]}

Gajewiak, J ^{[1
]}

机构：

[1] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

来源：

TETRAHEDRON | 2003年 / 59卷 / 50期

关键词：

camphorsulfonamides; diethylzinc; titanium tetrapropoxide; enantioselectivity;

D O I：

10.1016/j.tet.2003.10.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of several C-2-symmetric bissulfonamides is described, starting from camphorsulfonyl chloride and various aromatic as well as aliphatic diamines. These compounds have been used as ligands for titanium tetraisopropoxide promoted diethylzinc addition to benzaldehyde. The best enantiomeric excess obtained in this study was 67%. The stereochemical outcome of the reaction is highly influenced both by the structure of ligand and the reaction parameters. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：10009 / 10012

页数：4

共 8 条

[1] α-hydroxy carboxylic acids:: new ligands for diethylzinc additions to aldehydes [J].