Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella

被引：50

作者：

Gunasekera, SP

McCarthy, PJ

Longley, RE

Pomponi, SA

Wright, AE

Lobkovsky, E

Clardy, J

机构：

[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA

[2] Cornell Univ, Baker Lab, Dept Chem, Ithaca, NY 14853 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np980293y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Discorhabdin P (1), a new discorhabdin analogue, has been isolated from a deep-water marine sponge of the genus Batzella. Discorhabdin P (1) inhibited the phosphatase activity of calcineurin and the peptidase activity of CPP32. It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described.

引用

页码：173 / 175

页数：3

共 25 条

[1] BLUNT JW, 1990, NEW J CHEM, V14, P761
[2] NATURAL AND SYNTHETIC DERIVATIVES OF DISCORHABDIN-C, A CYTOTOXIC PIGMENT FROM THE NEW-ZEALAND SPONGE LATRUNCULIA CF BOCAGEI
COPP, BR
FULTON, KF
PERRY, NB
BLUNT, JW
MUNRO, MHG
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (26) : 8233 - 8238
[3] Faulkner DJ, 1998, NAT PROD REP, V15, P113
[4] Inhibition of ICE slows ALS in mice
Friedlander, RM
Brown, RH
Gagliardini, V
Wang, J
Yuan, JY
[J]. NATURE, 1997, 388 (6637) : 31 - 31
[5] Calcineurin: Not just a simple protein phosphatase
Guerini, D
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (02) : 271 - 275
[6] Dysidiolide: A novel protein phosphatase inhibitor from the Caribbean sponge Dysidea etheria de Laubenfels
Gunasekera, SP
McCarthy, PJ
KellyBorges, M
Lobkovsky, E
Clardy, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (36) : 8759 - 8760
[7] Inhibition of interleukin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
Hara, H
Friedlander, RM
Gagliardini, V
Ayata, C
Fink, K
Huang, ZH
ShimizuSasamata, M
Yuan, JY
Moskowitz, MA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) : 2007 - 2012
[8] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS
KERR, JFR
WYLLIE, AH
CURRIE, AR
[J]. BRITISH JOURNAL OF CANCER, 1972, 26 (04) : 239 - +
[9] Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
Kim, TW
Pettingell, WH
Jung, YK
Kovacs, DM
Tanzi, RE
[J]. SCIENCE, 1997, 277 (5324) : 373 - 376
[10] REVISED STRUCTURES OF PRIANOSIN-C AND PRIANOSIN-D, ANTINEOPLASTIC ALKALOIDS FROM THE OKINAWAN MARINE SPONGE PRIANOS-MELANOS
KOBAYASHI, J
CHENG, JF
YAMAMURA, S
ISHIBASHI, M
[J]. TETRAHEDRON LETTERS, 1991, 32 (09) : 1227 - 1228

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