Investigation of the electrochemical behavior of some catecholamines in the presence of 4-aminobenzoic acid

被引：22

作者：

Afkhami, A ^{[1
]}

Nematollahi, D ^{[1
]}

Madrakian, T ^{[1
]}

Khalafi, L ^{[1
]}

机构：

[1] Univ Bu Ali Sina, Fac Sci, Dept Chem, Hamadan 65174, Iran

来源：

ELECTROCHIMICA ACTA | 2005年 / 50卷 / 28期

关键词：

cyclic voltammetry; digital simulation; catecholamines;

D O I：

10.1016/j.electacta.2005.04.028

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Electrochemical oxidation of some catecholamines such as dopamine (1), L-dopa (2) and methyldopa (3) has been studied in the presence of 4-aminobenzoic acid (4). Some electrochemical techniques such as cyclic voltammetry using diagnostic criteria derived by Nicholson and Shain for various electrode mechanisms and control led-potential coulometry were used. Variation in cathodic peaks due to the competition between intramolecular and intermolecular Michael addition reaction was studied in various pH values, and the best conditions for reaction with 4-aminobenzoic acid was obtained. The results indicate an ECE mechanism. The observed homogeneous rate constant (k(obs)) for Michael addition reaction was estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results. Also, the Michael addition reaction rate constants (k(m)) were calculated using microscopic acidic dissociation constant of ammonium groups in 4aminobenzoic acid. The chemical oxidation reaction of catecholannines with periodate in the presence of 4-aminobenzoic acid was also studied spectrophotometrically. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5633 / 5640

页数：8

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