Progression of impairment in patients with vascular cognitive impairment without dementia

被引：245

作者：

Wentzel, C

Rockwood, K

MacKnight, C

Hachinski, V

Hogan, DB

Feldman, H

Ostbye, T

Wolfson, C

Gauthier, S

Verreault, R

McDowell, I

机构：

[1] Dalhousie Univ, QEII Hlth Sci Ctr, Div Geriatr Med, Halifax, NS B3H 2E1, Canada

[2] Univ Western Ontario, London, ON, Canada

[3] Univ Calgary, Calgary, AB T2N 1N4, Canada

[4] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[5] McGill Univ, Montreal, PQ, Canada

[6] Univ Laval, Quebec City, PQ, Canada

[7] Univ Ottawa, Ottawa, ON K1N 6N5, Canada

[8] Duke Univ, Med Ctr, Durham, NC USA

来源：

NEUROLOGY | 2001年 / 57卷 / 04期

关键词：

D O I：

10.1212/WNL.57.4.714

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Little is known about progression, short of dementia, in vascular cognitive impairment. In the Canadian Study of Health and Aging, 149 participants (79.3 +/- 6.7 years; 61%. women) were found to have vascular cognitive impairment, no dementia (CIND). After 5 years, 77 participants (52%) had died and 58 (46%) had developed dementia. Women were at greater risk of dementia (OR 2.1, 1.0 to 4.5). Of 32 participants alive without dementia, cognition had deteriorated in seven and improved in four. Half of those with vascular CIND developed dementia within 5 years, suggesting a target for preventive interventions.

引用

页码：714 / 716

页数：3

共 10 条

[1] COGNITIVE IMPAIRMENT IN THE NONDEMENTED ELDERLY - RESULTS FROM THE CANADIAN STUDY OF HEALTH AND AGING [J].