Amyloid-beta plaque growth in cognitively normal adults: Longitudinal [11C]Pittsburgh compound B data

被引：117

作者：

Vlassenko, Andrei G. ^{[2
,3
]}

Mintun, Mark A. ^{[2
,4
]}

Xiong, Chengjie ^{[3
,5
]}

Sheline, Yvette I. ^{[2
,3
,6
]}

Goate, Alison M. ^{[3
,6
]}

Benzinger, Tammie L. S. ^{[2
,3
]}

Morris, John C. ^{[1
,3
]}

机构：

[1] Washington Univ, Sch Med, Knight Alzheimer Dis Res Ctr, Dept Neurol, St Louis, MO 63108 USA

[2] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63108 USA

[3] Washington Univ, Sch Med, Charles F & Joanne Knight Alzheimer Dis Res Ctr, St Louis, MO 63108 USA

[4] Avid Radiopharmaceut, Philadelphia, PA USA

[5] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63108 USA

[6] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63108 USA

来源：

ANNALS OF NEUROLOGY | 2011年 / 70卷 / 05期

关键词：

ALZHEIMERS-DISEASE; FOLLOW-UP; PROGRESSION; DEPOSITION; PIB;

D O I：

10.1002/ana.22608

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyloid-beta (A beta) accumulation was evaluated with 2 [11C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated A beta deposition demonstrated subsequent A beta plaque growth (approximately 8.0% per year), and none reverted to a state of no A beta deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an e4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in A beta burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms. Ann Neurol 2011

引用

页码：857 / 861

页数：5

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