Nosocomial spread of Pseudomonas aeruginosa isolates expressing the metallo-β-lactamase VIM-2 in a hematology unit of a French Hospital

被引：31

作者：

Aubron, C

Poirel, L

Fortineau, N

Nicolas, P

Collet, L

Nordmann, P

机构：

[1] Hop Bicetre, Serv Bacteriol Virol, Assistance Publ Hop Paris, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France

[2] IMISSA, F-13998 Marseille, France

[3] Inst J Paoli I Calmettes, Dept Biol, F-13273 Marseille, France

来源：

MICROBIAL DRUG RESISTANCE | 2005年 / 11卷 / 03期

关键词：

D O I：

10.1089/mdr.2005.11.254

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

Dissemination of metallo-beta-lactamases (carbapenemases) was investigated retrospectively among ceftazidime- and imipenem-resistant Pseudomonas aeruginosa isolates in a hematology unit in Marseilles, France, from September, 1995, to March, 1999. Sixteen clinical isolates and 23 environmental strains were identified, with a same bla(VIM-2) gene that encoded a carbapenemase identified in Southern Europe and South Korea. Five different genotypes were identified among clinical and environmental P. aeruginosa isolates all harboring an similar to 45-kb plasmid with bla(VIM-2)-positive class 1 integrons varying in structures. This study identified a hidden reservoir of carbapenemase producers.

引用

页码：254 / 259

页数：6

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