Sialyl Lewisx: A "Pre-Organized Water Oligomer"?

被引：38

作者：

Binder, Florian P. C. ^{[1
]}

Lemme, Katrin ^{[1
]}

Preston, Roland C. ^{[1
]}

Ernst, Beat ^{[1
]}

机构：

[1] Univ Basel, Inst Mol Pharm, CH-4056 Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 29期

基金：

瑞士国家科学基金会;

关键词：

carbohydrates; E-selectin; glycomimetics; isothermal titration calorimetry; sialyl Lewisx; E-SELECTIN BINDING; CARBOHYDRATE LIGAND; BIOACTIVE CONFORMATION; CELL-ADHESION; RECOGNITION; ANALOGS; SLE(X); THERMODYNAMICS; ENTHALPY; AFFINITY;

D O I：

10.1002/anie.201202555

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Organized and released: Sialyl Lewis x (sLe x) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe x binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7327 / 7331

页数：5

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