An abiotic strategy for the enantioselective synthesis of erythromycin B

被引：23

作者：

Hergenrother, PJ ^{[1
]}

Hodgson, A ^{[1
]}

Judd, AS ^{[1
]}

Lee, WC ^{[1
]}

Martin, SF ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 28期

关键词：

asymmetric synthesis; cyclization; glycosylation; macrolactonization; natural products; total synthesis;

D O I：

10.1002/anie.200351136

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sweet success: The classical approach to macrolide antibiotics involves a macrocyclization followed by the introduction of the carbohydrate residue(s). Now for the first time, a glycosylated seco-acid (see scheme, left) was cyclized to give an intermediate that was converted into a naturally occurring macrolide, as exemplified by the synthesis of erythromycin B (right).

引用

页码：3278 / 3281

页数：4

共 37 条

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