Oxygen, oxidative stress, hypoxia, and heart failure

被引：1172

作者：

Giordano, FJ ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 03期

关键词：

D O I：

10.1172/JCI200524408

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.

引用

页码：500 / 508

页数：9

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