New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica -: 2.: Structure analysis

被引：21

作者：

Suzuki, Y

Ojika, M ^{[1
]}

Sakagami, Y

Kaida, K

Fudou, R

Kameyama, T

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Ajinomoto Co Inc, Pharmaceut Res Labs, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan

[3] Ajinomoto Co Inc, Cent Res Labs, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 01期

关键词：

D O I：

10.7164/antibiotics.54.22

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of new cyclic decadepsipeptides, clavariopsins A and B, were determined to be cyclo[-(R)-2-hydroxyisovaleryl-L-pipecolyl-L-MeVal-L-Val-L-MeAsp-L-Melle-L-Melle-Gly-L-MeVal-L-Try(OMe)-] and cyclo[-(R)-2-hydroxyisovaleryl-L-pipecolyl-L-MeIle-L-MeIle-Gly-L-MeVal-L-Tyr(OME)-], respectively, by spectroscopic analysis, especially using 2D NMR techniques. The absolute stereochemistry was elucidated by the advanced MARFEY'S method and chiral HPLC analysis.

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页码：22 / 28

页数：7

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