Pathologic parameters in the diagnosis and prognosis of primary cutaneous melanoma

被引：30

作者：

Byers, HR ^{[1
]}

Bhawan, J ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Dermatol, Dermatopathol Sect, Boston, MA 02118 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1998年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0889-8588(05)70020-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Significant histopathologic, immunohistochemical, and investigative studies conducted in the last 10 years and relevant to the diagnosis and prognosis of primary cutaneous melanoma are reviewed. Important recent concordance studies in the diagnosis of melanoma are discussed and the relevant histologic prognostic indicators, such as thickness, mitotic rate, number of tumor-infiltrating lymphocytes, regression, and ulceration, are summarized. The value of classifying melanoma into nontumorigenic radial growth and tumorigenic vertical growth phases as a model to predict outcome is contrasted with subclassification. Finally, a critical appraisal of established and emerging immunohistochemical markers for the diagnosis and prognosis of melanoma is presented.

引用

页码：717 / +

页数：21

共 68 条

[1] Discordance among expert pathologists in diagnosis of melanocytic neoplasms [J].

Ackerman, AB .

HUMAN PATHOLOGY, 1996, 27 (11) :1115-1116

[2] FOCAL ADHESION KINASE (P125(FAK)) EXPRESSION CORRELATES WITH MOTILITY OF HUMAN-MELANOMA CELL-LINES [J].

AKASAKA, T ;

VANLEEUWEN, RL ;

YOSHINAGA, IG ;

MIHM, MC ;

BYERS, HR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (01) :104-108

[3] EFFICACY OF 2-CM SURGICAL MARGINS FOR INTERMEDIATE-THICKNESS MELANOMAS (1 TO 4 MM) - RESULTS OF A MULTIINSTITUTIONAL RANDOMIZED SURGICAL TRIAL [J].

BALCH, CM ;

URIST, MM ;

KARAKOUSIS, CP ;

SMITH, TJ ;

TEMPLE, WJ ;

DRZEWIECKI, K ;

JEWELL, WR ;

BARTOLUCCI, AA ;

MIHM, MC ;

BARNHILL, R ;

WANEBO, HJ .

ANNALS OF SURGERY, 1993, 218 (03) :262-269

[4]

BALCH CM, 1979, SURGERY, V86, P343

[5]

BARNHILL RL, 1993, SEMIN DIAGN PATHOL, V10, P47

[6]

BARNHILL RL, 1992, LAB INVEST, V67, P331

[7] Mel-5: A novel antibody for differential diagnosis of epidermal pigmented lesions of the skin in paraffin-embedded sections [J].

Bhawan, J .

MELANOMA RESEARCH, 1997, 7 (01) :43-48

[8] THIN MALIGNANT MELANOMAS (LESS-THAN-1.5 MM) WITH METASTASIS - A HISTOLOGICAL STUDY AND SURVIVAL ANALYSIS [J].

BLESSING, K ;

MCLAREN, KM ;

MCLEAN, A ;

DAVIDSON, P .

HISTOPATHOLOGY, 1990, 17 (05) :389-395

[9] MIB-1 immunoreactivity correlates with metastatic dissemination in primary thick cutaneous melanoma [J].

Boni, R ;

Doguoglu, A ;

Burg, G ;

Muller, B ;

Dummer, R .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1996, 35 (03) :416-418

[10] ACTIN-BINDING PROTEIN EXPRESSION IN BENIGN AND MALIGNANT MELANOCYTIC PROLIFERATIONS [J].

BOUFFARD, D ;

DUNCAN, LM ;

HOWARD, CA ;

MIHM, MC ;

BYERS, HR .

HUMAN PATHOLOGY, 1994, 25 (07) :709-714

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