HLA-Cw alleles associated with HLA extended haplotypes and C2 deficiency

被引:11
作者
Clavijo, OP
Delgado, JC
Awdeh, ZL
Fici, D
Turbay, D
Alper, CA
Truedsson, L
Yunis, EJ
机构
[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[4] Ctr Blood Res, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
[6] Univ Lund, Dept Med Microbiol, Clin Immunol Sect, Lund, Sweden
来源
TISSUE ANTIGENS | 1998年 / 52卷 / 03期
关键词
c2; deficiency; extended haplotypes; HLA-Cw alleles; MHC;
D O I
10.1111/j.1399-0039.1998.tb03045.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
There are four NMC-linked complement genes, BE C2, C4A and C4B, that are inherited as single DNA units, known as complotypes. Extended haplotypes were initially defined by studying the distribution of complotypes in relation to HLA-B and HLA-DR loci in Caucasian families. In order to analyze the distribution of HLA-Cw alleles in relation to extended haplotypes, we studied a large panel of MHC homozygous and hetero zygous cell lines representing previously described Caucasian derived extended haplotypes and 14 patients with complete C2 deficiency. HLA alleles were assigned using sequence-specific oligonucleotide probe hybridization (SSOP). Family analysis served to assign haplotypes for heterozygous samples. We found distinctive HLA-Cw alleles for each independent extended haplotype. Their association in each instance was statistically significant. All patients with C2 deficiency carrying the haplotype [HLA-B18, S042, DR2] were associated with HLA-Cw*1203. These conserved allelic combinations may become an important tool for the study of human evolution and may contribute to the expeditious selection of prospective donors in clinical transplantation.
引用
收藏
页码:282 / 285
页数:4
相关论文
共 29 条
  • [1] AGNELLO V, 1972, J IMMUNOL, V108, P837
  • [2] MAJOR HISTOCOMPATIBILITY COMPLEX HAPLOTYPE STUDIES IN ASHKENAZI JEWISH PATIENTS WITH PEMPHIGUS-VULGARIS
    AHMED, AR
    YUNIS, EJ
    KHATRI, K
    WAGNER, R
    NOTANI, G
    AWDEH, Z
    ALPER, CA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) : 7658 - 7662
  • [3] SERUM COMPLEMENT SUPERGENES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN MAN (COMPLOTYPES)
    ALPER, CA
    RAUM, D
    KARP, S
    AWDEH, ZL
    YUNIS, EJ
    [J]. VOX SANGUINIS, 1983, 45 (01) : 62 - 67
  • [4] EXTENDED MAJOR HISTOCOMPATIBILITY COMPLEX HAPLOTYPES IN MAN - ROLE OF ALLELES ANALOGOUS TO MURINE TERT-MUTANTS
    ALPER, CA
    AWDEH, ZL
    RAUM, DD
    YUNIS, EJ
    [J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1982, 24 (02): : 276 - 285
  • [5] COMPLOTYPES AND EXTENDED HAPLOTYPES IN LABORATORY MEDICINE
    ALPER, CA
    AWDEH, ZL
    YUNIS, EJ
    [J]. COMPLEMENT AND INFLAMMATION, 1989, 6 (01) : 8 - 18
  • [6] ALPER CA, 1984, IMMUNOGENETICS, P50
  • [7] COMPLEMENT-HUMAN HISTOCOMPATIBILITY ANTIGEN HAPLOTYPES IN C2 DEFICIENCY
    AWDEH, ZL
    RAUM, DD
    GLASS, D
    AGNELLO, V
    SCHUR, PH
    JOHNSTON, RB
    GELFAND, EW
    BALLOW, M
    YUNIS, E
    ALPER, CA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (02) : 581 - 583
  • [8] Error rate for HLA-B antigen assignment by serology: implications for proficiency testing and utilization of DNA-based typing methods
    Bozon, MV
    Delgado, JC
    Selvakumar, A
    Clavijo, OP
    Salazar, M
    Ohashi, M
    Alosco, SM
    Russell, J
    Yu, N
    Dupont, B
    Yunis, EJ
    [J]. TISSUE ANTIGENS, 1997, 50 (04): : 387 - 394
  • [9] LOCUS-SPECIFIC AMPLIFICATION OF HLA CLASS-I GENES FROM GENOMIC DNA - LOCUS-SPECIFIC SEQUENCES IN THE FIRST AND 3RD INTRONS OF HLA-A, HLA-B, AND HLA-C ALLELES
    CEREB, N
    MAYE, P
    LEE, S
    KONG, Y
    YANG, SY
    [J]. TISSUE ANTIGENS, 1995, 45 (01): : 1 - 11
  • [10] THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION MARKED BY HSP70-1 AND HSP70-2 VARIANTS IS ASSOCIATED WITH CLOZAPINE-INDUCED AGRANULOCYTOSIS IN 2 DIFFERENT ETHNIC-GROUPS
    CORZO, D
    YUNIS, JJ
    SALAZAR, M
    LIEBERMAN, JA
    HOWARD, A
    AWDEH, Z
    ALPER, CA
    YUNIS, EJ
    [J]. BLOOD, 1995, 86 (10) : 3835 - 3840