Regulation and functions of Rho-associated kinase

被引：458

作者：

Amano, M

Fukata, Y

Kaibuchi, K

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cell Pharmacol, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nara Inst Sci & Technol, Div Signal Transduct, Ikoma 6300101, Japan

来源：

EXPERIMENTAL CELL RESEARCH | 2000年 / 261卷 / 01期

基金：

日本学术振兴会;

关键词：

Rho; Rho-associated kinase (Rho-kinase); myosin-binding subunit (MBS); myosin; actin; Ezrin/radixin/moesin (ERM); adducin; intermediate filament; LIM-kinase; collapsin response mediator protein-2 (CRMP2);

D O I：

10.1006/excr.2000.5046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase. (C) 2000 Academic Press.

引用

页码：44 / 51

页数：8

共 64 条

[1] Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
Amano, M
Chihara, K
Kimura, K
Fukata, Y
Nakamura, N
Matsuura, Y
Kaibuchi, K
[J]. SCIENCE, 1997, 275 (5304) : 1308 - 1311
[2] The COOH terminus of Rho-kinase negatively regulates Rho-kinase activity
Amano, M
Chihara, K
Nakamura, N
Kaneko, T
Matsuura, Y
Kaibuchi, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) : 32418 - 32424
[3] Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase
Amano, M
Chihara, K
Nakamura, N
Fukata, Y
Yano, T
Shibata, M
Ikebe, M
Kaibuchi, K
[J]. GENES TO CELLS, 1998, 3 (03) : 177 - 188
[4] Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
Amano, M
Ito, M
Kimura, K
Fukata, Y
Chihara, K
Nakano, T
Matsuura, Y
Kaibuchi, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) : 20246 - 20249
[5] Phosphorylation of collapsin response mediator protein-2 by Rho-kinase -: Evidence for two separate signaling pathways for growth cone collapse
Arimura, N
Inagaki, N
Chihara, K
Ménager, C
Nakamura, N
Amano, M
Iwamatsu, A
Goshima, Y
Kaibuchi, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (31) : 23973 - 23980
[6] THE SPECTRIN-ACTIN JUNCTION OF ERYTHROCYTE-MEMBRANE SKELETONS
BENNETT, V
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 988 (01) : 107 - 121
[7] A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons
Bito, H
Furuyashiki, T
Ishihara, H
Shibasaki, Y
Ohashi, K
Mizuno, K
Maekawa, M
Ishizaki, T
Narumiya, S
[J]. NEURON, 2000, 26 (02) : 431 - 441
[8] Regulation of cortical structure by the ezrin-radixin-moesin protein family
Bretscher, A
[J]. CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (01) : 109 - 116
[9] The Ulip family phosphoproteins - Common and specific properties
Byk, T
Ozon, S
Sobel, A
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 254 (01): : 14 - 24
[10] Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase
Chihara, K
Amano, M
Nakamura, N
Yano, T
Shibata, M
Tokui, T
Ichikawa, H
Ikebe, R
Ikebe, M
Kaibuchi, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (40) : 25121 - 25127

← 1 2 3 4 5 6 7 →