VEGF: an update on biological and therapeutic aspects

被引：329

作者：

Farrara, N ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, S San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(00)00153-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that the inhibition of VEGF activity may be beneficial for these conditions.

引用

页码：617 / 624

页数：8

共 108 条

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