The role of BH3-only proteins in the immune system

被引：486

作者：

Strasser, A ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 03期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1568

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Programmed cell death - also known as apoptosis - has a crucial role in the immune system of mammals and other animals. It removes useless cells and potentially dangerous cells, including lymphocytes, and is involved in killing pathogen-infected or damaged cells. Defects in this process have been found to cause or contribute to diseases of the immune system, including immunodeficiency, autoimmunity, lymphoma and leukaemia. This review describes BH3-only proteins, a pro-apoptotic subgroup of the BCL-2 family, and their role in the development and function of the immune system.

引用

页码：189 / 200

页数：12

共 125 条

[1] Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
Akashi, K
Kondo, M
vonFreedenJeffry, U
Murray, R
Weissman, IL
[J]. CELL, 1997, 89 (07) : 1033 - 1041
[2] Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
Akiyama, T
Bouillet, P
Miyazaki, T
Kadono, Y
Chikuda, H
Chung, UG
Fukuda, A
Hikita, A
Seto, H
Okada, T
Inaba, T
Sanjay, A
Baron, R
Kawaguchi, H
Oda, H
Nakamura, K
Strasser, A
Tanaka, S
[J]. EMBO JOURNAL, 2003, 22 (24) : 6653 - 6664
[3] FAS LIGAND MEDIATES ACTIVATION-INDUCED CELL-DEATH IN HUMAN T-LYMPHOCYTES
ALDERSON, MR
TOUGH, TW
DAVISSMITH, T
BRADDY, S
FALK, B
SCHOOLEY, KA
GOODWIN, RG
SMITH, CA
RAMSDELL, F
LYNCH, DH
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) : 71 - 77
[4] Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist bim
Bouillet, P
Cory, S
Zhang, LC
Strasser, A
Adams, JM
[J]. DEVELOPMENTAL CELL, 2001, 1 (05) : 645 - 653
[5] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
Bouillet, P
Metcalf, D
Huang, DCS
Tarlinton, DM
Kay, TWH
Köntgen, F
Adams, JM
Strasser, A
[J]. SCIENCE, 1999, 286 (5445) : 1735 - 1738
[6] BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Bouillet, P
Purton, JF
Godfrey, DI
Zhang, LC
Coultas, L
Puthalakath, H
Pellegrini, M
Cory, S
Adams, JM
Strasser, A
[J]. NATURE, 2002, 415 (6874) : 922 - 926
[7] BOYD JM, 1995, ONCOGENE, V11, P1921
[8] BCL-2, BCL-XL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
Cheng, EHYA
Wei, MC
Weiler, S
Flavell, RA
Mak, TW
Lindsten, T
Korsmeyer, SJ
[J]. MOLECULAR CELL, 2001, 8 (03) : 705 - 711
[9] A CONSERVED DOMAIN IN BAK, DISTINCT FROM BH1 AND BH2, MEDIATES CELL-DEATH AND PROTEIN-BINDING FUNCTIONS
CHITTENDEN, T
FLEMINGTON, C
HOUGHTON, AB
EBB, RG
GALLO, GJ
ELANGOVAN, B
CHINNADURAI, G
LUTZ, RJ
[J]. EMBO JOURNAL, 1995, 14 (22) : 5589 - 5596
[10] Solution structure of BID, an intracellular amplifier of apoptotic signaling
Chou, JJ
Li, HL
Salvesen, GS
Yuan, JY
Wagner, G
[J]. CELL, 1999, 96 (05) : 615 - 624

← 1 2 3 4 5 6 7 8 9 10 →