Toward on-chip X-ray analysis

被引:35
作者
Greaves, ED
Manz, A
机构
[1] Univ Simon Bolivar, Caracas 1080A, Venezuela
[2] ISAS, Inst Analyt Sci, D-44139 Dortmund, Germany
[3] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
来源
LAB ON A CHIP | 2005年 / 5卷 / 04期
关键词
D O I
10.1039/b415836a
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The possibility of performing chemical analysis and structure determinations with the use of X-rays in a microfluidic chip environment is explored. Externally generated radiation, radioisotope irradiation and on-chip generated X-rays were considered as excitation means for the performance of sample analysis with the techniques of X-ray fluorescence and diffraction. The absorption properties of chip-building materials by different radiation sources are reviewed and data on absorption coefficients calculated, upon which recommendations for optimisations with the use of various X-ray sources may be made. The capabilities and limitations of on-chip X-ray analysis are placed in perspective by preliminary experimental results of diffraction, fluorescence and on-chip X-ray generation experiments.
引用
收藏
页码:382 / 391
页数:10
相关论文
共 33 条
[1]  
*AMPT INC, COOL X MIN XRAY GEN
[2]  
*AMTEK INC, MIN XRAY GEN
[3]  
*AMTEK INC, LAS X
[4]   Micro total analysis systems. 2. Analytical standard operations and applications [J].
Auroux, PA ;
Iossifidis, D ;
Reyes, DR ;
Manz, A .
ANALYTICAL CHEMISTRY, 2002, 74 (12) :2637-2652
[5]   Comparative material characterization of historical and industrial samples by using a compact micro-XRF spectrometer [J].
Bichlmeier, S ;
Janssens, K ;
Heckel, J ;
Hoffmann, P ;
Ortner, HM .
X-RAY SPECTROMETRY, 2002, 31 (01) :87-91
[6]   Component selection for a compact micro-XRF spectrometer [J].
Bichlmeier, S ;
Janssens, K ;
Heckel, J ;
Gibson, D ;
Hoffmann, P ;
Ortner, HM .
X-RAY SPECTROMETRY, 2001, 30 (01) :8-14
[7]   ArtTAX -: a new mobile spectrometer for energy-dispersive micro X-ray fluorescence spectrometry on art and archaeological objects [J].
Bronk, H ;
Röhrs, S ;
Bjeoumikhov, A ;
Langhoff, N ;
Schmalz, J ;
Wedell, R ;
Gorny, HE ;
Herold, A ;
Waldschläger, U .
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 2001, 371 (03) :307-316
[8]  
Brown Sanborn C., 1959, BASIC DATA PLASMA PH
[9]   Pressure dependence of energetic (≤160 keV) focused electron beams arising from heated or cooled (LiNbO3) pyroelectric crystals [J].
Brownridge, JD ;
Shafroth, SM .
APPLIED PHYSICS LETTERS, 2003, 83 (07) :1477-1479
[10]   Self-focused electron beams produced by pyroelectric crystals on heating or cooling in dilute gases [J].
Brownridge, JD ;
Shafroth, SM .
APPLIED PHYSICS LETTERS, 2001, 79 (20) :3364-3366