Dendritic Discrimination of Temporal Input Sequences in Cortical Neurons

被引:319
作者
Branco, Tiago
Clark, Beverley A.
Haeusser, Michael [1 ]
机构
[1] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England
基金
英国惠康基金;
关键词
NEOCORTICAL PYRAMIDAL NEURONS; BASAL DENDRITES; SYNAPTIC INTEGRATION; ACTION-POTENTIALS; SPIKES; PLASTICITY; REPRESENTATION; MECHANISM; NETWORK; CELLS;
D O I
10.1126/science.1189664
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The detection and discrimination of temporal sequences is fundamental to brain function and underlies perception, cognition, and motor output. By applying patterned, two-photon glutamate uncaging, we found that single dendrites of cortical pyramidal neurons exhibit sensitivity to the sequence of synaptic activation. This sensitivity is encoded by both local dendritic calcium signals and somatic depolarization, leading to sequence-selective spike output. The mechanism involves dendritic impedance gradients and nonlinear synaptic N-methyl-D-aspartate receptor activation and is generalizable to dendrites in different neuronal types. This enables discrimination of patterns delivered to a single dendrite, as well as patterns distributed randomly across the dendritic tree. Pyramidal cell dendrites can thus act as processing compartments for the detection of synaptic sequences, thereby implementing a fundamental cortical computation.
引用
收藏
页码:1671 / 1675
页数:5
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