Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study

被引：18

作者：

Banus, Sander

Bottema, Renske W. B.

Siezen, Christine L. E.

Vandebriel, Rob J.

Reimerink, Johan

Mommers, Monique

Koppelman, Gerard H.

Hoebee, Barbara

Thijs, Carel

Postma, Dirkje S.

Kimman, Tjeerd G.

Stelma, Foekje F.

机构：

[1] Natl Inst Publ Hlth & Environm, Lab Vaccine Preventable Dis, RIVM, NL-3720 BA Bilthoven, Netherlands

[2] Natl Inst Publ Hlth & Environm, RIVM, Lab Toxicol Pathol & Genet, NL-3720 BA Bilthoven, Netherlands

[3] Natl Inst Publ Hlth & Environm, RIVM, Diagnost Lab Infect Dis, NL-3720 BA Bilthoven, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pulmonol, Groningen, Netherlands

[5] Maastricht Univ, Dept Emergency Care, Maastricht, Netherlands

[6] Maastricht Univ, Publ Hlth Res Inst, Maastricht, Netherlands

[7] Nutr & Toxicol Res Inst, Maastricht, Netherlands

[8] Univ Groningen, Univ Med Ctr Groningen, Beatrix Children Hosp, Dept Pediat Pulmonol, Groningen, Netherlands

[9] Maastricht Univ, Dept Med Microbiol, Maastricht, Netherlands

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2007年 / 14卷 / 10期

关键词：

D O I：

10.1128/CVI.00175-07

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

引用

收藏

页码：1377 / 1380

页数：4

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