Does brain natriuretic peptide interact with the immune system after cardiac transplantation?

被引:12
作者
Shaw, Steven M. [1 ]
Fildes, James [1 ]
Yonan, Nizar [1 ]
Williams, Simon G. [1 ]
机构
[1] NHS Hosp Fdn Trust, Univ Hosp S Manchester, Transplant Ctr, NW Reg Cardiac & Transplant Unit, Manchester, Lancs, England
关键词
brain natriuretic peptide; cardiac transplantation; immune system;
D O I
10.1097/01.tp.0000295851.24889.bf
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
Brain natriuretic peptide (BNP) is a marker of diagnosis and prognosis in patients with chronic heart failure. Stored in ventricular myocytes, it is released during ventricular stretch and increased transmural pressure. However, BNP behaves unusually after cardiac transplantation, with a failure to return to normal levels. This raises a question over whether other processes are involved in both its, production and secretion. Several studies suggest BNP levels are associated with allograft rejection and coronary graft vasculopathy. Both of these processes have a single denominator in common, the activated immune system. This over-view considers further evidence suggesting that BNP interacts with the immune system after cardiac transplantation.
引用
收藏
页码:1377 / 1381
页数:5
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