Predicting enzyme function from protein sequence

被引：26

作者：

Minshull, J ^{[1
]}

Ness, JE ^{[1
]}

Gustafsson, C ^{[1
]}

Govindarajan, S ^{[1
]}

机构：

[1] DNA 2 0, Menlo Pk, CA 94025 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 02期

关键词：

D O I：

10.1016/j.cbpa.2005.02.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are two main reasons to try to predict an enzyme's function from its sequence. The first is to identify the components and thus the functional capabilities of an organism, the second is to create enzymes with specific properties. Genomics, expression analysis, proteomics and metabonomics are largely directed towards understanding how information flows from DNA sequence to protein functions within an organism. This review focuses on information flow in the opposite direction: the applicability of what is being learned from natural enzymes to improve methods for catalyst design.

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页码：202 / 209

页数：8

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