Pluronic® F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin

被引:91
作者
Morishita, M
Barichello, JM
Takayama, K
Chiba, Y
Tokiwa, S
Nagai, T
机构
[1] Hoshi Univ, Fac Pharmaceut Sci, Dept Pharmaceut, Shinagawa Ku, Tokyo 1428501, Japan
[2] Nippon Suisan Kaisya Ltd, Cent Res Lab, Hachioji, Tokyo 1920906, Japan
关键词
insulin; Pluronic F-127 gels; buccal absorption; unsaturated fatty acids; hypoglycemic effect;
D O I
10.1016/S0378-5173(00)00615-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study investigated the release profiles of insulin from Pluronic F-127 (PF-127) gel containing unsaturated fatty acids such as oleic acid (18:1), eicosapentaenoic acid (20:5) or docosahexaenoic acid (22:6) and hypoglycemic effect of insulin following the buccal administration of the gel formulations in normal rats. Insulin release from the gels decreased in the presence of unsaturated fatty acids. Remarkable and continuous hypoglycemia was induced by all PF-127 gels (insulin dose, 25 IU/kg) containing unsaturated fatty acids. PF-127 gels containing oleic acid showed the highest pharmacological availability (15.9 +/- 7.9%). Our finding demonstrate that 20% PF-127 gels containing unsaturated fatty acids are potential formulations for the buccal delivery of insulin. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:289 / 293
页数:5
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