How a plant lectin recognizes high mannose oligosaccharides1[C][OA]

被引：18

作者：

Garcia-Pino, Abel

Buts, Lieven

Wyns, Lode

Imberty, Anne

Loris, Remy

机构：

[1] Vrije Univ Brussel, Lab Voor Ultrastruct, B-1050 Brussels, Belgium

[2] VIB, Dept Mol & Cellular Interact, B-1050 Brussels, Belgium

[3] Univ Grenoble 1, CNRS, Ctr Rech Macromol Vegetales, F-38041 Grenoble 9, France

来源：

PLANT PHYSIOLOGY | 2007年 / 144卷 / 04期

关键词：

STRUCTURAL BASIS; CARBOHYDRATE INTERACTIONS; LEGUME LECTINS; CONCANAVALIN-A; CRYSTAL-STRUCTURE; CYANOVIRIN-N; BINDING; OLIGOSACCHARIDES; COMPLEX; SPECIFICITIES;

D O I：

10.1104/pp.107.100867

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Mana(1-2) Mana(1-6)[Mana(1-3)] Mana(1-. Isothermal titration calorimetry titration experiments using Man-5, Man-9, and the Man-9-containing glycoprotein soybean (Glycine max) agglutinin as ligands confirm the monovalence of Man-9 and show a 4-times higher affinity for Man-9 when it is presented to P. angolensis seed lectin in a glycoprotein context.

引用

页码：1733 / 1741

页数：9

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