Failure to detect Chlamydia pneumoniae in calcific and degenerative arteriosclerotic aortic valves excised during open heart surgery

被引：35

作者：

Andreasen, JJ

Farholt, S

Jensen, JS

机构：

[1] Univ Copenhagen, Gentofte Hosp, Dept Cardiothorac Surg R, DK-2900 Copenhagen, Denmark

[2] Statens Serum Inst, Neisseria Dept, DK-2300 Copenhagen, Denmark

来源：

APMIS | 1998年 / 106卷 / 07期

关键词：

Chlamydia pneumoniae; aortic valves; atherosclerosis;

D O I：

10.1111/j.1699-0463.1998.tb00217.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Chlamydia pneumoniae has been associated with atherosclerosis, although no causal association has been established. Employing culture and polymerase chain reaction in aortic valves with calcific and degenerative arteriosclerotic changes from 23 non-consecutive patients undergoing aortic valve replacement, C. pneumoniae was not detected in any of the valves. 19/22 patients had serological evidence of past infection with C. pneumoniae. Our findings do not provide supportive evidence for the hypothesis that C. pneumoniae is associated with calcific or degenerative arteriosclerotic aortic heart valve disease.

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收藏

页码：717 / 720

页数：4

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