Property-based design: Optimization of drug absorption and pharmacokinetics

被引:478
作者
van de Waterbeemd, H [1 ]
Smith, DA [1 ]
Beaumont, K [1 ]
Walker, DK [1 ]
机构
[1] Pfizer Global Res & Dev, Sandwich Labs, Dept Drug Metab, Sandwich CT13 9NJ, Kent, England
关键词
D O I
10.1021/jm000407e
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:1313 / 1333
页数:21
相关论文
共 186 条
[1]   The correlation and prediction of the solubility of compounds in water using an amended solvation energy relationship [J].
Abraham, MH ;
Le, J .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (09) :868-880
[2]   On the partition of ampholytes: Application to blood-brain distribution [J].
Abraham, MH ;
TakacsNovak, K ;
Mitchell, RC .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (03) :310-315
[3]   Can we learn to distinguish between "drug-like" and "nondrug-like" molecules? [J].
Ajay ;
Walters, WP ;
Murcko, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (18) :3314-3324
[4]   Designing libraries with CNS activity [J].
Ajay ;
Bemis, GW ;
Murcko, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (24) :4942-4951
[5]   A THEORETICAL BASIS FOR A BIOPHARMACEUTIC DRUG CLASSIFICATION - THE CORRELATION OF IN-VITRO DRUG PRODUCT DISSOLUTION AND IN-VIVO BIOAVAILABILITY [J].
AMIDON, GL ;
LENNERNAS, H ;
SHAH, VP ;
CRISON, JR .
PHARMACEUTICAL RESEARCH, 1995, 12 (03) :413-420
[6]   CORRELATION BETWEEN ORAL-DRUG ABSORPTION IN HUMANS AND APPARENT DRUG PERMEABILITY COEFFICIENTS IN HUMAN INTESTINAL EPITHELIAL (CACO-2) CELLS [J].
ARTURSSON, P ;
KARLSSON, J .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) :880-885
[7]   Caco-2 monolayers in experimental and theoretical predictions of drug transport [J].
Artursson, P ;
Palm, K ;
Luthman, K .
ADVANCED DRUG DELIVERY REVIEWS, 1996, 22 (1-2) :67-84
[8]   SELECTIVE PARACELLULAR PERMEABILITY IN 2 MODELS OF INTESTINAL-ABSORPTION - CULTURED MONOLAYERS OF HUMAN INTESTINAL EPITHELIAL-CELLS AND RAT INTESTINAL SEGMENTS [J].
ARTURSSON, P ;
UNGELL, AL ;
LOFROTH, JE .
PHARMACEUTICAL RESEARCH, 1993, 10 (08) :1123-1129
[9]   High-throughput measurements of solubility profiles [J].
Avdeef, A .
PHARMACOKINETIC OPTIMIZATION IN DRUG RESEARCH: BIOLOGICAL, PHYSICOCHEMICAL, AND COMPUTATIONAL STRATEGIES, 2001, :305-325
[10]   pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs [J].
Avdeef, A ;
Box, KJ ;
Comer, JEA ;
Hibbert, C ;
Tam, KY .
PHARMACEUTICAL RESEARCH, 1998, 15 (02) :209-215