Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl-vinylsilane strategy

被引：46

作者：

Kira, K ^{[1
]}

Isobe, M ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Organ Chem Lab, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(01)00286-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route to the BCDE rings of ciguatoxin 1B has been explored through acetylene biscobalthexacarbonyl complex and vinylsilane strategy. The key issues in the current synthesis are (i) ether ring cyclization by means of the acetylene cobalt complex and (ii) reductive decomplexation of the product endo-complexes into the corresponding vinylsilanes. A sequential cyclization route is also described along this line. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2821 / 2824

页数：4

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