Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones

被引：221

作者：

Li, Shiming ^{[1
]}

Pan, Min-Hsiung ^{[2
]}

Lo, Chih-Yu ^{[3
]}

Tan, Di ^{[1
]}

Wang, Yu ^{[1
]}

Shahidi, Fereidoon ^{[4
]}

Ho, Chi-Tang ^{[1
,5
]}

机构：

[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[2] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung 811, Taiwan

[3] Natl Chiayi Univ, Dept Food Sci, Chiayi 600, Taiwan

[4] Mem Univ Newfoundland, Dept Biochem, St John, NF A1B 3X9, Canada

[5] Natl Taiwan Univ, Grad Inst Food Sci & Technol, Taipei 10764, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2009年 / 1卷 / 01期

关键词：

Polymethoxyflavones; Hydroxylated polymethoxyflavones; Anti-inflammatory; Anti-cancer; Anti-atherogenic properties; Bioavailability; Permeability; Solubility; Absorption; CITRUS POLYMETHOXYLATED FLAVONES; CACO-2 CELL MONOLAYERS; RAT-LIVER MICROSOMES; ORANGE PEEL EXTRACT; IN-VITRO; CARCINOMA-CELLS; CANCER CELLS; SYNOVIAL FIBROBLASTS; SKIN INFLAMMATION; MOUSE MACROPHAGES;

D O I：

10.1016/j.jff.2008.09.003

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones exist exclusively in citrus genus, especially in the citrus peels which have been used as herbal medicine for several diseases for thousands of years. In this review, the natural occurrence, isolation and separation of PMFs; synthetic scheme of hydroxylated PMF preparation, especially the reaction mechanism of preparation of 5-hydroxylated PMFs; biotransformation and metabolic fate of PMFs; the preliminary study on PMF bioavailability and the close relationship among solubility, permeability, absorption and oral bioavailability are summarized. The published bioactivity data on anti-inflammatory, anti-cancer and anti-atherogenic properties of PMFs have also been detailed along with a report of new findings of hydroxylated PMFs and their potent biological activities. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2 / 12

页数：11

共 61 条

[1]

Bracke ME, 2002, ADV EXP MED BIOL, V505, P135

[2]

Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat [J].

Breinholt, V ;

Lauridsen, ST ;

Dragsted, LO .

XENOBIOTICA, 1999, 29 (12) :1227-1240

[3]

In vitro metabolism of genistein and tangeretin by human and murine cytochrome p450s [J].

Breinholt, VM ;

Rasmussen, SE ;

Brosen, K ;

Friedberg, TH .

PHARMACOLOGY & TOXICOLOGY, 2003, 93 (01) :14-22

[4]

APIGENIN AND TANGERETIN ENHANCE GAP JUNCTIONAL INTERCELLULAR COMMUNICATION IN RAT-LIVER EPITHELIAL-CELLS [J].

CHAUMONTET, C ;

BEX, V ;

GAILLARDSANCHEZ, I ;

SEILLANHEBERDEN, C ;

SUSCHETET, M ;

MARTEL, P .

CARCINOGENESIS, 1994, 15 (10) :2325-2330

[5]

Tangeretin suppresses IL-1β-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells [J].

Chen, Kuan-Hunq ;

Weng, Meng-Shih ;

Lin, Jen-Kun .

BIOCHEMICAL PHARMACOLOGY, 2007, 73 (02) :215-227

[6]

Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits [J].

Choi, Soo-Youn ;

Ko, Hee-Chul ;

Ko, Soo-Youn ;

Hwang, Joon-Ho ;

Park, Ji-Gweon ;

Kang, Shin-Hae ;

Han, Sang-Hun ;

Yun, Su-Hyun ;

Kim, Se-Jae .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (04) :772-778

[7]

Inflammation and cancer [J].

Coussens, LM ;

Werb, Z .

NATURE, 2002, 420 (6917) :860-867

[8]

Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells [J].

Eguchi, Ai ;

Murakami, Akira ;

Ohigashi, Hajime .

FEBS LETTERS, 2006, 580 (13) :3321-3328

[9]

MECHANISM OF INTESTINAL-ABSORPTION OF RANITIDINE AND ONDANSETRON - TRANSPORT ACROSS CACO-2 CELL MONOLAYERS [J].

GAN, LS ;

HSYU, PH ;

PRITCHARD, JF ;

THAKKER, D .

PHARMACEUTICAL RESEARCH, 1993, 10 (12) :1722-1725

[10]

TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers [J].

Hamada, Mika ;

Satsu, Hideo ;

Natsume, Yayoi ;

Nishiumi, Shin ;

Fukuda, Itsuko ;

Ashida, Hitoshi ;

Shimizu, Makoto .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (23) :8891-8898

← 1 2 3 4 5 6 7 →