Two intra-amygdaloid pathways to the central amygdala exhibit different mechanisms of long-term potentiation

被引：33

作者：

Fu, Y ^{[1
]}

Shinnick-Gallagher, P ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2005年 / 93卷 / 05期

关键词：

D O I：

10.1152/jn.00871.2004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synaptic plasticity in the amygdala is thought to underlie aversive or rewarding learning and emotional memories. In this study, different mechanisms were found to underlie synaptic plasticity in lateral ( LA) and basolateral (BLA) amygdala pathways to the primary output nucleus of the amygdala, the central amygdala (CeA). Specifically, 1) long-term potentiation (LTP) at the BLA-CeA synapses was independent of inhibition and mediated through N-methyl-D-aspartate receptors (NMDARs) and L-type voltage-gated calcium channels (VGCCs), and 2) LTP in the LA-CeA pathway was gated by inhibition and mediated through VGCCs but not NMDARs.

引用

页码：3012 / 3015

页数：4

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