FoXS: a web server for rapid computation and fitting of SAXS profiles

被引：409

作者：

Schneidman-Duhovny, Dina ^{[1
,2
]}

Hammel, Michal ^{[3
]}

Sali, Andrej ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, Dept Pharmaceut Chem, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Calif Inst Quantitat Biosci QB3, San Francisco, CA 94158 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

基金：

美国国家卫生研究院;

关键词：

X-RAY-SCATTERING; SMALL-ANGLE SCATTERING; BIOLOGICAL MACROMOLECULES; NEUTRON-SCATTERING; PROTEIN COMPLEXES; ASSEMBLIES; SOLVENT; MODELS;

D O I：

10.1093/nar/gkq461

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small angle X-ray scattering (SAXS) is an increasingly common technique for low-resolution structural characterization of molecules in solution. SAXS experiment determines the scattering intensity of a molecule as a function of spatial frequency, termed SAXS profile. SAXS profiles can contribute to many applications, such as comparing a conformation in solution with the corresponding X-ray structure, modeling a flexible or multi-modular protein, and assembling a macromolecular complex from its subunits. These applications require rapid computation of a SAXS profile from a molecular structure. FoXS (Fast X-Ray Scattering) is a rapid method for computing a SAXS profile of a given structure and for matching of the computed and experimental profiles. Here, we describe the interface and capabilities of the FoXS web server (http://salilab.org/foxs).

引用

页码：W540 / W544

页数：5

共 30 条

[1] Announcing the worldwide Protein Data Bank [J].