Epigenetic alterations in gastric carcinogenesis

被引：66

作者：

Choi, IS ^{[1
]}

Wu, TT ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX USA

来源：

CELL RESEARCH | 2005年 / 15卷 / 04期

关键词：

epigenetic alterations; gastric carcinogenesis; chronic gastritis; intestinal metaplasia; dysplasia/adenoma; adenocarcinoma;

D O I：

10.1038/sj.cr.7290293

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gastric cancer is believed to result in part from the accumulation of multiple genetic alterations leading to oncogene overexpression and tumor suppressor loss. Epigenetic alterations as a distinct and crucial mechanism to silence a variety of methylated tissue-specific and imprinted genes, have been extensively studied in gastric carcinoma and play important roles in gastric carcinogenesis. This review will briefly discuss the basic aspects of DNA methylation and CpG island methylation, in particular the epigenetic alterations of certain critical genes implicated in gastric carcinogenesis and its relevance of clinical implications.

引用

页码：247 / 254

页数：8

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