The effects of D-1 or D-2 dopamine receptor blockade on zif/268 and preprodynorphin gene expression in rat forebrain following a short-term cocaine binge

被引：46

作者：

Daunais, JB ^{[1
]}

McGinty, JF ^{[1
]}

机构：

[1] E CAROLINA UNIV, SCH MED, DEPT ANAT & CELL BIOL, GREENVILLE, NC 27858 USA

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 35卷 / 1-2期

关键词：

SCH; 23390; sulpiride; opioid; in situ hybridization; striatum; sensorimotor cortex; psychostimulant; immediate early gene; transcription factors;

D O I：

10.1016/0169-328X(95)00226-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Selective D-1 or D-2 dopamine receptor antagonists were used to investigate the transynaptic regulation of mRNAs coding for the opioid peptide, preprodynorphin, and the nuclear transcription factor, zif/268 after an acute cocaine binge. Rats were injected intraperitoneally with the D-1 receptor antagonist, SCH 23390, or the D-2 receptor antagonist, sulpiride, 30 min prior to 3 hourly injections of saline or 20 mg/kg cocaine and killed 1 h after the final injection. Behavioral ratings indicated that SCH 23390 blocked, whereas sulpiride augmented, cocaine-induced stereotypical behaviors. Striatal sections were hybridized with oligonucleotides coding for zif/268 and preprodynorphin. Quantitative image analysis of autoradiograms revealed that (1) SCH 23390 completely suppressed basal and cocaine binge-induced zif/268 mRNA in the striatal and cerebral cortical areas examined; (2) sulpiride enhanced basal levels of zif/268 mRNA in the medial caudate and dorsomedial shell of the nucleus accumbens; (3) sulpiride partially blocked cocaine binge-induced levels of zif/268 mRNA in the dorsal striatum but had no effect in sensory cortex; (4) SCH 23390, but not sulpiride, significantly reduced the constitutive expression of preprodynorphin mRNA; and (5) SCH 23390 and sulpiride blocked cocaine binge-induced expression of preprodynorphin mRNA in the dorsal striatum.

引用

页码：237 / 248

页数：12

共 63 条

[31] CLOZAPINE AND HALOPERIDOL PRODUCE A DIFFERENTIAL PATTERN OF IMMEDIATE-EARLY GENE-EXPRESSION IN RAT CAUDATE-PUTAMEN, NUCLEUS-ACCUMBENS, LATERAL SEPTUM AND ISLANDS-OF-CALLEJA [J].

MACGIBBON, GA ;

LAWLOR, PA ;

BRAVO, R ;

DRAGUNOW, M .

MOLECULAR BRAIN RESEARCH, 1994, 23 (1-2) :21-32

[32] THE DOPAMINE-D1 RECEPTOR ANTAGONIST SCH-23390 DECREASES THE MESSENGER-RNA LEVELS OF THE TRANSCRIPTION FACTOR ZIF268 (KROX-24) IN ADULT-RAT INTACT STRIATUM - AN INSITU HYBRIDIZATION STUDY [J].

MAILLEUX, P ;

ZHANG, F ;

VANDERHAEGHEN, JJ .

NEUROSCIENCE LETTERS, 1992, 147 (02) :182-184

[33]

MAISONNEUVE IM, 1994, J PHARMACOL EXP THER, V268, P916

[34] A COMPARISON OF D1-RECEPTOR BINDING AND MESSENGER-RNA IN RAT-BRAIN USING RECEPTOR AUTORADIOGRAPHIC AND INSITU HYBRIDIZATION TECHNIQUES [J].

MANSOUR, A ;

MEADORWOODRUFF, JH ;

ZHOU, Q ;

CIVELLI, O ;

AKIL, H ;

WATSON, SJ .

NEUROSCIENCE, 1992, 46 (04) :959-971

[35] SELECTIVE ANTAGONISM OF DOPAMINE D-1 AND D-2 RECEPTORS DOES NOT BLOCK THE DEVELOPMENT OF BEHAVIORAL SENSITIZATION TO COCAINE [J].

MATTINGLY, BA ;

HART, TC ;

LIM, K ;

PERKINS, C .

PSYCHOPHARMACOLOGY, 1994, 114 (02) :239-242

[36] COCAINE-INDUCED BEHAVIOR - DOPAMINE-D1 RECEPTOR ANTAGONISM BY SCH-23390 PREVENTS EXPRESSION OF CONDITIONED SENSITIZATION FOLLOWING REPEATED ADMINISTRATION OF COCAINE [J].

MCCREARY, AC ;

MARSDEN, CA .

NEUROPHARMACOLOGY, 1993, 32 (04) :387-391

[37] DOPAMINERGIC ANTAGONISM WITHIN THE NUCLEUS-ACCUMBENS OR THE AMYGDALA PRODUCES DIFFERENTIAL-EFFECTS ON INTRAVENOUS COCAINE SELF-ADMINISTRATION UNDER FIXED AND PROGRESSIVE RATIO SCHEDULES OF REINFORCEMENT [J].

MCGREGOR, A ;

ROBERTS, DCS .

BRAIN RESEARCH, 1993, 624 (1-2) :245-252

[38] MODULATION OF STRIATAL [GLUTAMIC-H-3 ACID RELEASE BY DOPAMINERGIC DRUGS [J].

MITCHELL, PR ;

DOGGETT, NS .

LIFE SCIENCES, 1980, 26 (24) :2073-2081

[39]

MORATALLA R, 1992, J NEUROSCI, V12, P2609

[40] DIFFERENTIAL EXPRESSION OF C-FOS AND ZIF268 IN RAT STRIATUM AFTER HALOPERIDOL, CLOZAPINE, AND AMPHETAMINE [J].

NGUYEN, TV ;

KOSOFSKY, BE ;

BIRNBAUM, R ;

COHEN, BM ;

HYMAN, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4270-4274

← 1 2 3 4 5 6 7 →