Effective, nonsensitizing vaccination with culture filtrate proteins against virulent Mycobacterium bovis infections in mice

被引：35

作者：

Bosio, CM ^{[1
]}

Orme, IM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol, Mycobacterial Res Labs, Ft Collins, CO 80523 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 10期

关键词：

D O I：

10.1128/IAI.66.10.5048-5051.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccination of mice with Mycobacterium bovis culture filtrate proteins (CFP), prepared in a variety of adjuvants (aluminum hydroxide, Quil-A, and dimethyldioctyldecyl ammonium bromide [DDA]), provided significant protection against an aerosol challenge of virulent nl. bovis. Additionally, vaccination with CFP in DDA or Quil-A did not sensitize mice to ill bovis purified protein derivative.

引用

页码：5048 / 5051

页数：4

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