Nuclear Receptors in Liver Disease

被引：241

作者：

Wagner, Martin ^{[2
,3
]}

Zollner, Gernot ^{[2
]}

Trauner, Michael ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, A-1090 Vienna, Austria

[2] Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, Lab Expt & Mol Hepatol, Graz, Austria

[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

HEPATOLOGY | 2011年 / 53卷 / 03期

关键词：

D O I：

10.1002/hep.24148

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as well as liver regeneration, inflammation, fibrosis, cell differentiation, and tumor formation. Derangements of nuclear receptor regulation and genetic variants may contribute to the pathogenesis and progression of liver diseases. This places nuclear receptors into the frontline for novel therapeutic approaches for a broad range of hepatic disorders and diseases including cholestatic and fatty liver disease, drug hepatotoxicity, viral hepatitis, liver fibrosis, and cancer. (HEPATOLOGY 2011;53:1023-1034)

引用

页码：1023 / 1034

页数：12

共 7 条

[1]

Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases [J].