Costimulation pathways in host immune responses to allogeneic hepatocytes.

被引：31

作者：

Bumgardner, GL ^{[1
]}

Li, J ^{[1
]}

Heininger, M ^{[1
]}

Orosz, CG ^{[1
]}

机构：

[1] Ohio State Univ, Med Ctr, Dept Surg, Div Transplantat, Columbus, OH 43210 USA

来源：

TRANSPLANTATION | 1998年 / 66卷 / 12期

关键词：

D O I：

10.1097/00007890-199812270-00047

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. This study investigated the role of the CD28/B7 (blocked by CTLA4Ig) and CD40/CD40L (blocked by MR1) costimulation pathways on in vivo host T-cell- mediated immune responses to allogeneic hepatocytes. Methods. Survival of allogeneic hepatocytes (H-2(q)) in C57BL/6 (H-2(b)) mice untreated or treated with MR1, CTLA4Ig, L6 (control fusion protein), or a combination of MR1 and CTLA4Ig fusion protein was determined. Results. Median survival time for hepatocellular allografts was 10, 84, 10, 10, and 84 days in untreated (n=10) MR1-treated (n=7) (P<.0001), CTLA4Ig-treated (n=7) (P=0.02), L6-treated (n=3) (P, not significant), and the combination of MR1- and CTLA4Ig-treated (n=6) (P=0.0003) groups, respectively. Conclusions. Host treatment with MR1, but not CTLA4Ig prolonged hepatocellular allograft survival. These data suggest that CD28/B7 interactions appear relatively unimportant, whereas CD40/CD40L interactions provide critical costimulator signals for T-cell-dependent immune responses to allogeneic hepatocytes.

引用

页码：1841 / 1845

页数：5

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