The nucleosome: From genomic organization to genomic regulation

被引：505

作者：

Khorasanizadeh, S ^{[1
]}

机构：

[1] Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

CELL | 2004年 / 116卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(04)00044-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electron micrographs first confirmed that the eukaryotic genome is organized into repeating disk-shaped nucleosomal units composed of histories and their associated DNA. Those images made clear the function of the nucleosome in packaging and condensing the genome. Today, nucleosomes are recognized as highly dynamic units through which the eukaryotic genome can be regulated with epigenetically heritable consequences. This review focuses on the conserved protein structures that mobilize and remodel nucleosomes and specifically mark and recognize their histone and DNA components. These events directly impact DNA transcription, replication, recombination, and repair.

引用

页码：259 / 272

页数：14

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