TPA and proteolysis in the neurovascular unit

被引:171
作者
Lo, EH
Broderick, JP
Moskowitz, MA
机构
[1] Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA USA
[2] Massachusetts Gen Hosp, Dept Neurol, Neuroprotect Res Lab, Charlestown, MA USA
[3] Harvard Univ, Sch Med, Program Neurosci, Charlestown, MA USA
[4] Univ Cincinnati, Dept Neurol, Cincinnati, OH USA
[5] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol,Neurovasc Regulat & Stroke Lab, Charlestown, MA USA
[6] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurosurg,Neurovasc Regulat & Stroke Lab, Charlestown, MA USA
关键词
Advances in Stroke; blood-brain barrier; matrix metalloproteinase; proteolysis; reperfusion injury; tissue plasminogen activator;
D O I
10.1161/01.STR.0000115164.80010.8A
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:354 / 356
页数:3
相关论文
共 36 条
[1]   Blood-brain barrier disruption and matrix metalloproteinase-9 expression during, reperfusion injury - Mechanical versus embolic focal ischemia in spontaneously hypertensive rats [J].
Aoki, T ;
Sumii, T ;
Mori, T ;
Wang, XY ;
Lo, EH .
STROKE, 2002, 33 (11) :2711-2717
[2]   Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia [J].
Asahi, M ;
Wang, XY ;
Mori, T ;
Sumii, T ;
Jung, JC ;
Moskowitz, MA ;
Fini, ME ;
Lo, EH .
JOURNAL OF NEUROSCIENCE, 2001, 21 (19) :7724-7732
[3]   Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke [J].
Castellanos, M ;
Leira, R ;
Serena, J ;
Pumar, JM ;
Lizasoain, I ;
Castillo, J ;
Dávalos, A .
STROKE, 2003, 34 (01) :40-45
[4]   Amyloid β-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells [J].
Davis, J ;
Wagner, MR ;
Zhang, WB ;
Xu, F ;
Van Nostrand, WE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (21) :19054-19061
[5]   Cerebral microvessel responses to focal ischemia [J].
del Zoppo, GJ ;
Mabuchi, T .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (08) :879-894
[6]   Matrix metalloproteinases in vascular remodeling and atherogenesis - The good, the bad, and the ugly [J].
Galis, ZS ;
Khatri, JJ .
CIRCULATION RESEARCH, 2002, 90 (03) :251-262
[7]  
Hacke W, 1999, NEUROLOGY, V53, pS3
[8]   LRP: a multifunctional scavenger and signaling receptor [J].
Herz, J ;
Strickland, DK .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (06) :779-784
[9]   Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients - Influence of different therapies [J].
Horstmann, S ;
Kalb, P ;
Koziol, J ;
Gardner, H ;
Wagner, S .
STROKE, 2003, 34 (09) :2165-2170
[10]   Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injury [J].
Indyk, JA ;
Chen, ZL ;
Tsirka, SE ;
Strickland, S .
NEUROSCIENCE, 2003, 116 (02) :359-371