F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases

被引：90

作者：

Praticò, D

Rokach, J

Lawson, J

FitzGerald, GA ^{[1
]}

机构：

[1] Univ Penn, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

[2] Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA

[3] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2004年 / 128卷 / 1-2期

关键词：

lipid peroxidation; oxidative sress; inflammation; atherosclerosis; Alzheimer's disease; animal models;

D O I：

10.1016/j.chemphyslip.2003.09.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isoprostanes are a new class of lipids, isomers of conventional enzymatically derived prostaglandins, which are produced in vivo primarily by a free radical-catalyzed peroxidation of polyunsaturated fatty acids. F-2-isoprostanes, isomers of the enzyme-derived prostaglandin F-2alpha, are the most studied species. Because of their mechanisms of formation, specific structural features that distinguish them from other free radical-generated products and chemical stability, they provide a reliable index of the oxidative component of several diseases in vivo. Consistent data suggest that formation of F-2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress. Moreover, measurement of F-2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：165 / 171

页数：7

共 75 条

[1] Cardiovascular responses to the isoprostanes iPF2α-III and iPE2-III are mediated via the thromboxane A2 receptor in vivo [J].