Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

被引：85

作者：

Welters, HJ

Tadayyon, M

Scarpello, JHB

Smith, SA

Morgan, NG

机构：

[1] Peninsula Med Sch, Inst Biomed & Clin Sci, Plymouth PL6 8BX, Devon, England

[2] GlaxoSmithKline Pharmaceut, Harlow, Essex, England

[3] Univ Keele, Sch Med, Keele ST5 5BG, Staffs, England

来源：

FEBS LETTERS | 2004年 / 560卷 / 1-3期

关键词：

beta-cell; lipotoxicity; apoptosis; diabetes; interleukin-1; beta; palmitoleate;

D O I：

10.1016/S0014-5793(04)00079-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-chain saturated fatty acids are cytotoxic to pancreatic P-cells while shorter-chain saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty acids are not, however, inert since they inhibit the pro-apototic effects of saturated molecules. In the present work we show that the mono-unsaturates palmitoleate (C16:1) or oleate (C18:1) also cause marked inhibition of apoptosis induced by exposure of clonal BRIN-BD11 beta-cells to serum withdrawal or a combination of interleukin-1beta plus interferon-gamma. This response was dose-dependent and not accompanied by changes in NO formation. Taken together, the results suggest that mono-unsaturated fatty acids regulate a distal step common to several apoptotic pathways in pancreatic beta-cells. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：103 / 108

页数：6

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